Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis

Table 6

Cox proportional hazards model showing the predictive value of upstream CRP expression (cutoff > 2.9%) toward MACE occurrence during 18 months of follow-up.

	Univariate model			Multivariate model
	HR	95% CI^†	value	HR	95% CI	value
MACEs^‡
Upstream CRP	6.22	1.49–26.05	0.012	8.57	1.89–38.77	0.005
Age	0.96	0.90–1.03	0.286	0.93	0.84–1.02	0.142
Gender, male	1.01	0.30–3.46	0.984	0.63	0.144–2.81	0.550
hs-CRP	0.78	0.57–1.06	0.114	0.49	0.23–1.01	0.053
Statin use	1.65	0.48–5.64	0.423	1.41	0.32–6.22	0.648

HR: hazards ratio.
^†CI: confidence interval.
^‡MACEs: major adverse cardiovascular events.
CRP: c-reactive protein.
hs-CRP: high sensitivity c-reactive protein.