Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2016, Article ID 9453745, 15 pages
http://dx.doi.org/10.1155/2016/9453745
Research Article

Disruption of Tumor Necrosis Factor Receptor-Associated Factor 5 Exacerbates Murine Experimental Colitis via Regulating T Helper Cell-Mediated Inflammation

1Department of Gastroenterology/Hepatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
2The Hubei Clinical Center & Key Laboratory of Intestinal & Colorectal Diseases, Wuhan 430071, China

Received 6 November 2015; Revised 25 February 2016; Accepted 7 March 2016

Academic Editor: Julio Galvez

Copyright © 2016 Jian Shang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Kaser, S. Zeissig, and R. S. Blumberg, “Inflammatory bowel disease,” Annual Review of Immunology, vol. 28, pp. 573–621, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. W. Strober and I. J. Fuss, “Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases,” Gastroenterology, vol. 140, no. 6, pp. 1756–1767, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. C. L. Maynard and C. T. Weaver, “Intestinal effector T cells in health and disease,” Immunity, vol. 31, no. 3, pp. 389–400, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Fujino, A. Andoh, S. Bamba et al., “Increased expression of interleukin 17 in inflammatory bowel disease,” Gut, vol. 52, no. 1, pp. 65–70, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. M. F. Neurath, S. Finotto, and L. H. Glimcher, “The role of TH1/TH2 polarization in mucosal immunity,” Nature Medicine, vol. 8, no. 6, pp. 567–573, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. I. J. Fuss, M. Neurath, M. Boirivant et al., “Disparate CD4+ Lamina Propria (LP) lymphokine secretion profiles in inflammatory Bowel disease: Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5,” Journal of Immunology, vol. 157, no. 3, pp. 1261–1270, 1996. View at Google Scholar · View at Scopus
  7. S. Wirtz, C. Neufert, B. Weigmann, and M. F. Neurath, “Chemically induced mouse models of intestinal inflammation,” Nature Protocols, vol. 2, no. 3, pp. 541–546, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Y. Oh, K.-A. Cho, J. L. Kang, K. H. Kim, and S.-Y. Woo, “Comparison of experimental mouse models of inflammatory bowel disease,” International Journal of Molecular Medicine, vol. 33, no. 2, pp. 333–340, 2014. View at Publisher · View at Google Scholar · View at Scopus
  9. J. R. Bradley and J. S. Pober, “Tumor necrosis factor receptor-associated factors (TRAFs),” Oncogene, vol. 20, no. 44, pp. 6482–6491, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Xie, J. Poovassery, L. L. Stunz et al., “Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes,” Journal of Leukocyte Biology, vol. 90, no. 6, pp. 1149–1157, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Clark, O. Takeuchi, S. Akira, and P. Cohen, “The TRAF-associated protein TANK facilitates cross-talk within the IκB kinase family during Toll-like receptor signaling,” Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 41, pp. 17093–17098, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. Q. Zhou and R. L. Geahlen, “The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells,” Oncogene, vol. 28, no. 10, pp. 1348–1356, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. P.-Y. B. Au and W.-C. Yeh, “Physiological roles and mechanisms of signaling by TRAF2 and TRAF5,” Advances in Experimental Medicine and Biology, vol. 597, pp. 32–47, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Zotti, P. Vito, and R. Stilo, “The seventh ring: exploring TRAF7 functions,” Journal of Cellular Physiology, vol. 227, no. 3, pp. 1280–1284, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. J. M. Hildebrand, Z. Yi, C. M. Buchta, J. Poovassery, L. L. Stunz, and G. A. Bishop, “Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions,” Immunological Reviews, vol. 244, no. 1, pp. 55–74, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Tada, T. Okazaki, S. Sakon et al., “Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-κB activation and protection from cell death,” The Journal of Biological Chemistry, vol. 276, no. 39, pp. 36530–36534, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. H. Nakano, S. Sakon, H. Koseki et al., “Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 17, pp. 9803–9808, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Akiba, H. Nakano, S. Nishinaka et al., “CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-κB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-κB-inducing kinase,” Journal of Biological Chemistry, vol. 273, no. 21, pp. 13353–13358, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Nakano, H. Oshima, W. Chung et al., “TRAF5, an activator of NF-κB and putative signal transducer for the lymphotoxin-β receptor,” The Journal of Biological Chemistry, vol. 271, no. 25, pp. 14661–14664, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. C. M. Buchta and G. A. Bishop, “TRAF5 negatively regulates TLR signaling in B lymphocytes,” Journal of Immunology, vol. 192, no. 1, pp. 145–150, 2014. View at Publisher · View at Google Scholar · View at Scopus
  21. T. So, S. Salek-Ardakani, H. Nakano, C. F. Ware, and M. Croft, “TNF receptor-associated factor 5 limits the induction of Th2 immune responses,” Journal of Immunology, vol. 172, no. 7, pp. 4292–4297, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. J. Kraus, J. S. Haring, and G. A. Bishop, “TNF receptor-associated factor 5 is required for optimal T cell expansion and survival in response to infection,” Journal of Immunology, vol. 181, no. 11, pp. 7800–7809, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. H. S. Cooper, S. N. S. Murthy, R. S. Shah, and D. J. Sedergran, “Clinicopathologic study of dextran sulfate sodium experimental murine colitis,” Laboratory Investigation, vol. 69, no. 2, pp. 238–250, 1993. View at Google Scholar · View at Scopus
  24. F. Obermeier, G. Kojouharoff, W. Hans, J. Schölmerich, V. Gross, and W. Falk, “Interferon-gamma (IFN-γ)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice,” Clinical and Experimental Immunology, vol. 116, no. 2, pp. 238–245, 1999. View at Publisher · View at Google Scholar · View at Scopus
  25. B. Weigmann, I. Tubbe, D. Seidel, A. Nicolaev, C. Becker, and M. F. Neurath, “Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue,” Nature Protocols, vol. 2, no. 10, pp. 2307–2311, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Oh and S. Ghosh, “NF-κB: roles and regulation in different CD4+ T-cell subsets,” Immunological Reviews, vol. 252, no. 1, pp. 41–51, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. I. Atreya, R. Atreya, and M. F. Neurath, “NF-κB in inflammatory bowel disease,” Journal of Internal Medicine, vol. 263, no. 6, pp. 591–596, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. S. N. Harbour, C. L. Maynard, C. L. Zindl, T. R. Schoeb, and C. T. Weaver, “Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 22, pp. 7061–7066, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. A.-M. Globig, N. Hennecke, B. Martin et al., “Comprehensive intestinal T helper cell profiling reveals specific accumulation of IFN-γ+IL-17+coproducing CD4+ T cells in active inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 20, no. 12, pp. 2321–2329, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. H.-P. Liu, A. T. Cao, T. Feng et al., “TGF-β converts Th1 cells into Th17 cells through stimulation of Runx1 expression,” European Journal of Immunology, vol. 45, no. 4, pp. 1010–1018, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Wang, J. Godec, K. Ben-Aissa et al., “The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells,” Immunity, vol. 40, no. 3, pp. 355–366, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. K. Ghoreschi, A. Laurence, X.-P. Yang et al., “Generation of pathogenic TH 17 cells in the absence of TGF-β 2 signalling,” Nature, vol. 467, no. 7318, pp. 967–971, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. N. Martin-Orozco, Y. Chung, S. H. Chang, Y.-H. Wang, and C. Dong, “Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells,” European Journal of Immunology, vol. 39, no. 1, pp. 216–224, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Stevceva, P. Pavli, A. Husband, A. Ramsay, and W. F. Doe, “Dextran sulphate sodium-induced colitis is ameliorated in interleukin 4 deficient mice,” Genes and Immunity, vol. 2, no. 6, pp. 309–316, 2001. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Okamura, K. Yoh, M. Ojima, N. Morito, and S. Takahashi, “Overexpression of GATA-3 in T cells accelerates dextran sulfate sodium-induced colitis,” Experimental Animals, vol. 63, no. 2, pp. 133–140, 2014. View at Publisher · View at Google Scholar · View at Scopus
  36. P. J. Barnes and M. Karin, “Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases,” The New England Journal of Medicine, vol. 336, no. 15, pp. 1066–1071, 1997. View at Publisher · View at Google Scholar · View at Scopus
  37. G. Bonizzi and M. Karin, “The two NF-κB activation pathways and their role in innate and adaptive immunity,” Trends in Immunology, vol. 25, no. 6, pp. 280–288, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. J. Wei and J. Feng, “Signaling pathways associated with inflammatory bowel disease,” Recent Patents on Inflammation and Allergy Drug Discovery, vol. 4, no. 2, pp. 105–117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. J. Das, C.-H. Chen, L. Yang, L. Cohn, P. Ray, and A. Ray, “A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation,” Nature Immunology, vol. 2, no. 1, pp. 45–50, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Gerondakis and U. Siebenlist, “Roles of the NF-kappaB pathway in lymphocyte development and function,” Cold Spring Harbor Perspectives in Biology, vol. 2, no. 5, Article ID a000182, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. L. Wang, Y. Lu, H. Guan et al., “Tumor necrosis factor receptor-associated factor 5 is an essential mediator of ischemic brain infarction,” Journal of Neurochemistry, vol. 126, no. 3, pp. 400–414, 2013. View at Publisher · View at Google Scholar · View at Scopus
  42. Z. Bian, J. Dai, N. Hiroyasu et al., “Disruption of tumor necrosis factor receptor associated factor 5 exacerbates pressure overload cardiac hypertrophy and fibrosis,” Journal of Cellular Biochemistry, vol. 115, no. 2, pp. 349–358, 2014. View at Publisher · View at Google Scholar · View at Scopus