Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure

<div>Possible signaling mechanism for GPx-1 regulation of the UPR. Evidence presented in this study indicates that following smoke exposure GPx-1 prevents ER stress (a). However, in the disease-state GPx-1 expression is subdued and results in enhanced UPR (b). RSV infection significantly contributes to reduced GPx-1 expression that coincides with enhanced UPR.</div>

Mediators of Inflammation

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Figure 8

Figure 8: Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure 