Systemic and Local Administration of Antimicrobial and Cell Therapies to Prevent Methicillin-Resistant Staphylococcus epidermidis-Induced Femoral Nonunions in a Rat Model

Figure 8

Histological analysis (H&E) at the day of explantation. The representative panel shows H&E staining of the femurs in all the experimental groups. The panels depict an overview of the samples, scale bar 1 mm. WB: woven bone; LB: lamellar bone; PR: periosteal reaction; FV: fibrovascular tissue; MH: myeloid hyperplasia; vascular infiltrates (black arrow); alteration of cortical bone (green arrow). For the l-rBMSCs group, (a) a specific area containing fibrovascular tissue and polymorphonucleated cells is reported in the big black box (scale bar 200 µm) and (b) the presence of giant cells in the small black box (scale bar 100 µm) is reported. For the PC group, (c) a specific area with fibrovascular tissue is reported in the big red box (scale bar 200 µm) and (d) the myeloid hyperplasia is shown in the small red box (scale bar 200 µm).