Simultaneous Inhibition of PGE2 and PGI2 Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models
Analgesic effect of compound I and celecoxib in adjuvant-induced chronic inflammatory pain in rats. (a) Time course of pain score. Male Lewis rats received a single, right hind-paw intradermal injection of M. butyricum (100 g/0.05 mL/paw) in a liquid paraffin emulsion on Day 0. At Day 19, animals with established hyperalgesia (pain score = 5) were orally administered compounds or 0.5% MC. Pain response was examined 1, 2, 3, and 4 h after administration. (b) Effect of compound I and celecoxib on inflamed tissue prostanoids’ production in adjuvant-induced chronic inflammatory pain model. Inflamed paw was obtained after the last measurement of pain score. Results are shown as the mean ± SEM ( = 6/group). The statistical analysis was performed by Steel’s test and Dunnett’s test for pain score (a) and prostanoids’ content (b), respectively. ; ; for compound treated versus 0.5% MC (0 mg/kg) treated animals.