Simultaneous Inhibition of PGE₂ and PGI₂ Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models

Figure 6

Analgesic effect of CJ-023423 and/or RO3244019 in adjuvant-induced chronic inflammatory pain model. Male Lewis rats received a single, right hind-paw intradermal injection of M. butyricum (100 g/0.05 mL/paw) in a liquid paraffin emulsion on Day 0. At Day 19, animals with established hyperalgesia (pain score = 5) were orally administered compounds or 0.5% MC. Pain response was examined 1, 2, 3, and 4 h after administration. Results are shown as the mean ± SEM ( = 6/group). The statistical analysis was performed by Steel’s test for multiple comparisons. for compound treated versus 0.5% MC (0 mg/kg) treated animals.