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Mediators of Inflammation
Volume 2016, Article ID 9856538, 10 pages
http://dx.doi.org/10.1155/2016/9856538
Research Article

Identification of a Novel lincRNA-p21-miR-181b-PTEN Signaling Cascade in Liver Fibrosis

1Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
2Department of Gastroenterology, Songjiang Hospital Affiliated Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 201600, China
3Department of Gastroenterology, Shanghai Songjiang Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China
4Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
5Key Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

Received 7 April 2016; Revised 21 June 2016; Accepted 3 July 2016

Academic Editor: Fumio Tsuji

Copyright © 2016 Fujun Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. L. Friedman, “Mechanisms of hepatic fibrogenesis,” Gastroenterology, vol. 134, no. 6, pp. 1655–1669, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. S. L. Friedman, “Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver,” Physiological Reviews, vol. 88, no. 1, pp. 125–172, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. R. W. Carthew and E. J. Sontheimer, “Origins and Mechanisms of miRNAs and siRNAs,” Cell, vol. 136, no. 4, pp. 642–655, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. R. Schickel, B. Boyerinas, S.-M. Park, and M. E. Peter, “MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death,” Oncogene, vol. 27, no. 45, pp. 5959–5974, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. X. Tu, H. Zhang, J. Zhang et al., “MicroRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway,” Journal of Pathology, vol. 234, no. 1, pp. 46–59, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. He, C. Huang, X. Sun, X.-R. Long, X.-W. Lv, and J. Li, “MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4,” Cellular Signalling, vol. 24, no. 10, pp. 1923–1930, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Zheng, C. Wu, Z. Lin et al., “Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation—a novel mechanism suppressing liver fibrosis,” The FEBS Journal, vol. 281, no. 1, pp. 88–103, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. M. L. Alvarez, M. Khosroheidari, E. Eddy, and J. Kiefer, “Role of microRNA 1207-5P and its host gene, the long non-coding RNA Pvt1, as mediators of extracellular matrix accumulation in the kidney: implications for diabetic nephropathy,” PLoS ONE, vol. 8, no. 10, Article ID e77468, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. X. Shi, M. Sun, H. Liu, Y. Yao, and Y. Song, “Long non-coding RNAs: a new frontier in the study of human diseases,” Cancer Letters, vol. 339, no. 2, pp. 159–166, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. He, Y.-T. Wu, C. Huang et al., “Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis,” Biochimica et Biophysica Acta—Molecular Basis of Disease, vol. 1842, no. 11, pp. 2204–2215, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Zheng, P. Dong, Y. Mao et al., “lincRNA-p21 inhibits hepatic stellate cell activation and liver fibrogenesis via p21,” The FEBS Journal, vol. 282, no. 24, pp. 4810–4821, 2015. View at Publisher · View at Google Scholar
  12. E.-B. Bian, C. Huang, T.-T. Ma et al., “DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats,” Toxicology and Applied Pharmacology, vol. 264, no. 1, pp. 13–22, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Wu, J. Cai, Y. Han et al., “LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity,” Circulation, vol. 130, no. 17, pp. 1452–1465, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Zheng, Z. Lin, P. Dong et al., “Activation of hepatic stellate cells is suppressed by microRNA-150,” International Journal of Molecular Medicine, vol. 32, no. 1, pp. 17–24, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. T. D. Schmittgen and K. J. Livak, “Analyzing real-time PCR data by the comparative CT method,” Nature Protocols, vol. 3, no. 6, pp. 1101–1108, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. He, C. Huang, S.-P. Zhang, X. Sun, X.-R. Long, and J. Li, “The potential of microRNAs in liver fibrosis,” Cellular Signalling, vol. 24, no. 12, pp. 2268–2272, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Dooley, B. Delvoux, M. Streckert et al., “Transforming growth factor β signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts: TGFβ signal transduction during transdifferentiation of hepatic stellate cells,” FEBS Letters, vol. 502, no. 1-2, pp. 4–10, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Lin and A. Chen, “Activation of peroxisome proliferator-activated receptor-γ by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells,” Laboratory Investigation, vol. 88, no. 5, pp. 529–540, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. B. Xiong, Y. Cheng, L. Ma, and C. Zhang, “MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells,” International Journal of Oncology, vol. 42, no. 1, pp. 219–228, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. X. Zheng, J. Li, C. Peng et al., “MicroRNA-24 induces cisplatin resistance by targeting PTEN in human tongue squamous cell carcinoma,” Oral Oncology, vol. 51, no. 11, pp. 998–1003, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. S.-Y. Yan, M.-M. Chen, G.-M. Li, Y.-Q. Wang, and J.-G. Fan, “MiR-32 induces cell proliferation, migration, and invasion in hepatocellular carcinoma by targeting PTEN,” Tumor Biology, vol. 36, no. 6, pp. 4747–4755, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. K. Ohta, H. Hoshino, J. Wang et al., “MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A,” Oncotarget, vol. 6, no. 5, pp. 3211–3224, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. Z. Wu, B. He, J. He, and X. Mao, “Upregulation of miR-153 promotes cell proliferation via downregulation of the PTEN tumor suppressor gene in human prostate cancer,” Prostate, vol. 73, no. 6, pp. 596–604, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Lei, Y. Huang, and W. Gong, “miR-205 promotes the growth, metastasis and chemoresistance of NSCLC cells by targeting PTEN,” Oncology Reports, vol. 30, no. 6, pp. 2897–2902, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Yang, W. Kong, L. He et al., “MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN,” Cancer Research, vol. 68, no. 2, pp. 425–433, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Zheng, C. Wu, Z. Xu et al., “Hepatic stellate cell is activated by microRNA-181b via PTEN/Akt pathway,” Molecular and Cellular Biochemistry, vol. 398, no. 1-2, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Huang, S. Nayak, R. Jankowitz, N. E. Davidson, and S. Oesterreich, “Epigenetics in breast cancer: what's new?” Breast Cancer Research, vol. 13, no. 6, article 225, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Cooper, J. Guo, Y. Yan et al., “Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides,” Nucleic Acids Research, vol. 37, no. 13, pp. 4518–4531, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Yu, Z. Lu, J. Cai et al., “MALAT1 functions as a competing endogenous RNA to mediate Rac1 expression by sequestering miR-101b in liver fibrosis,” Cell Cycle, vol. 14, no. 24, pp. 3885–3896, 2015. View at Publisher · View at Google Scholar
  30. N. Dimitrova, J. R. Zamudio, R. M. Jong et al., “LincRNA-p21 activates p21 in cis to promote polycomb target gene expression and to enforce the G1/S checkpoint,” Molecular Cell, vol. 54, no. 5, pp. 777–790, 2014. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Wang, Z.-J. Lei, Y. Guo et al., “miRNA-regulated delivery of lincRNA-p21 suppresses β-catenin signaling and tumorigenicity of colorectal cancer stem cells,” Oncotarget, vol. 6, no. 35, pp. 37852–37870, 2015. View at Publisher · View at Google Scholar · View at Scopus
  32. I. Pitha-Rowe, K. Liby, D. Royce, and M. Sporn, “Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN,” Investigative Ophthalmology & Visual Science, vol. 50, no. 11, pp. 5339–5347, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Besson, S. M. Robbins, and V. W. Yong, “PTEN/MMAC1/TEP1 in signal transduction and tumorigenesis,” European Journal of Biochemistry, vol. 263, no. 3, pp. 605–611, 1999. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Liu, H. Li, L. Guo et al., “Mechanisms involved in phosphatidylinositol 3-kinase pathway mediated up-regulation of the mu opioid receptor in lymphocytes,” Biochemical Pharmacology, vol. 79, no. 3, pp. 516–523, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. V. K. Bhaskara, C. Sundaram, and P. P. Babu, “pERK, pAkt and pBad: a possible role in cell proliferation and sustained cellular survival during tumorigenesis and tumor progression in ENU induced transplacental glioma rat model,” Neurochemical Research, vol. 31, no. 9, pp. 1163–1170, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Takashima, C. J. Parsons, K. Ikejima, S. Watanabe, E. S. White, and R. A. Rippe, “The tumor suppressor protein PTEN inhibits rat hepatic stellate cell activation,” Journal of Gastroenterology, vol. 44, no. 8, pp. 847–855, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. B. Wang, W. Li, K. Guo, Y. Xiao, Y. Wang, and J. Fan, “MiR-181b promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients,” Biochemical and Biophysical Research Communications, vol. 421, no. 1, pp. 4–8, 2012. View at Publisher · View at Google Scholar · View at Scopus