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Mediators of Inflammation
Volume 2016, Article ID 9856538, 10 pages
http://dx.doi.org/10.1155/2016/9856538
Research Article

Identification of a Novel lincRNA-p21-miR-181b-PTEN Signaling Cascade in Liver Fibrosis

1Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
2Department of Gastroenterology, Songjiang Hospital Affiliated Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai 201600, China
3Department of Gastroenterology, Shanghai Songjiang Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China
4Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
5Key Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

Received 7 April 2016; Revised 21 June 2016; Accepted 3 July 2016

Academic Editor: Fumio Tsuji

Copyright © 2016 Fujun Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Fig.S1 The effects of PTEN siRNA, Ad-lincRNA-p21 or miR-181b inhibitor on the protein expression of PTEN. (A) PTEN protein was reduced by PTEN siRNA1 or siRNA2. Cells were transfected with PTEN siRNA for 48 h. (B) PTEN protein was increased by Ad-lincRNA-p21, which was further enhanced by miR-181b inhibitor. Cells were transduced with Ad-lincRNA-p21 for 48 h and treated with miR-181b inhibitor for additional 48 h. GAPDH was used as internal control. Each value is the mean ± SD of three experiments. *P<0.05 compared with the control and #P<0.05 compared with Ad-lincRNA-p21 group.

  1. Supplementary Material