Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells

Figure 2

IL-33 is expressed in alveolar type II cells. BALB/c mice were culled 7 days after endotracheal administration of AdDel70 or AdOSM vector and left lungs analyzed by specific immunohistochemistry for IL-33 as described in Materials and Methods. (a) Representative micrographs of lungs from AdDel70 or AdOSM as indicated with IL-33 as brown-red signal. (c) Quantification of nuclear IL-33⁺ epithelial cells per 400x field ( mice/group) in lung sections of mice given AdDel70 or AdOSM vector (day 7). Lung sections at day 7 from BALB/c mice given AdOSM were stained for (b) IL-33, (d) CD31, and (e) prosurfactant protein C (SPC). And statistical significance is indicated, where ().

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