Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients
Table 4
The multiple Cox regression analysis results for death risk.
Outcome types
CVD death
All-cause death
Covariates
HR
95% CI
value
HR
95% CI
value
CD16+ monocytes, %
Q4 versus Q3
12.81
3.72
44.09
<0.001
3.26
1.49
7.14
0.003
Q4 versus Q2
30.85
7.12
133.8
<0.001
5.28
2.07
13.49
<0.001
Q3 versus Q2
2.41
0.58
10.03
0.227
1.62
0.61
4.29
0.333
Follow-up time ≤ 3.5 years
Q1 versus Q2
1.63
0.15
17.33
0.685
0.9
0.26
3.16
0.875
Q4 versus Q1
18.92
2.17
164.9
0.008
5.84
1.71
19.98
0.005
Q3 versus Q1
1.48
0.16
13.47
0.73
1.79
0.52
6.17
0.358
Follow-up time > 3.5 years
Q1 versus Q2
10.9
2.42
48.96
0.002
4.38
1.45
13.24
0.009
Q4 versus Q1
2.83
0.81
9.86
0.102
1.21
0.44
3.29
0.716
Q3 versus Q1
0.22
0.05
0.91
0.037
0.37
0.13
1.07
0.067
Baseline medical condition
CeVD history, yes versus no
6.98
2.18
22.3
0.001
2.74
1.41
5.32
0.003
CAD history, yes versus no
44.57
13.1
151.7
<0.001
9.4
4.53
19.48
<0.001
CAD history versus CeVD history
6.39
1.79
22.8
0.004
3.43
1.34
8.75
0.01
Age, >q2 versus others
2.88
1.14
7.28
0.025
2.36
1.24
4.52
0.009
Cholesterol, >q2 versus others
2.98
1.19
7.44
0.02
—
—
—
—
Platelet, >q2 versus others
7.23
2.66
19.67
<0.001
3.99
2.04
7.79
<0.001
Cr
≤q1 versus others
4.26
1.82
10
<0.001
—
—
—
—
≤q2 versus others
—
—
—
—
4.49
2.31
8.75
<0.001
UA, ≤q1 or >q3 versus others
7.38
2.47
22.01
<0.001
2.5
1.35
4.62
0.003
SBP, >q2 versus others
5.11
1.92
13.59
0.001
—
—
—
—
DBP, ≤q1 or >q3 versus others
7.43
2.62
21.06
<0.001
4.08
1.98
8.4
<0.001
rTG, >q3 versus others
0.18
0.07
0.47
<0.001
0.21
0.09
0.47
<0.001
Ferritin, >q3 versus others
—
—
—
—
0.45
0.23
0.87
0.018
Note: the abbreviations are the same as those indicated in Table 1. q1, q2, and q3 denoted the three quartiles—the first quartile, median, and the third quartile—of each covariate and the values were listed in Table 1. Q1, Q2, Q3, and Q4 here denoted the four ascending categories derived from the categorized CD16+ monocyte levels by its three quartiles. indicates values of less than 0.05.
