Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2017 (2017), Article ID 1089028, 14 pages
https://doi.org/10.1155/2017/1089028
Research Article

Patchoulene Epoxide Isolated from Patchouli Oil Suppresses Acute Inflammation through Inhibition of NF-κB and Downregulation of COX-2/iNOS

1Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
2Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
3The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
4Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan 523808, China

Correspondence should be addressed to Zi-Ren Su and Janis Ya-Xian Zhan

Received 12 January 2017; Revised 5 June 2017; Accepted 13 June 2017; Published 25 July 2017

Academic Editor: Rajesh Singh

Copyright © 2017 Jia-Li Liang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Lawrence, D. A. Willoughby, and D. W. Gilroy, “Anti-inflammatory lipid mediators and insights into the resolution of inflammation,” Nature Reviews Immunology, vol. 2, no. 10, pp. 787–795, 2002. View at Publisher · View at Google Scholar · View at Scopus
  2. M. T. Mansouri, A. A. Hemmati, B. Naghizadeh, S. A. Mard, A. Rezaie, and B. Ghorbanzadeh, “A study of the mechanisms underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats,” Indian Journal of Pharmacology, vol. 47, no. 3, p. 292, 2014. View at Google Scholar
  3. Y. Y. Li, S. S. Huang, M. M. Lee, J. S. Deng, and G. J. Huang, “Anti-inflammatory activities of cardamonin from Alpinia katsumadai through heme oxygenase-1 induction and inhibition of NF-κB and MAPK signaling pathway in the carrageenan-induced paw edema,” International Immunopharmacology, vol. 25, no. 2, pp. 332–339, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Madhusudana, B. Shireesha, V. G. M. Naidu, S. Ramakrishna, B. Narsaiah, and A. R. Rao, “Anti-inflammatory potential of thienopyridines as possible alternative to NSAIDs,” European Journal of Pharmacology, vol. 678, no. 678, pp. 48–54, 2012. View at Google Scholar
  5. M. Fornai, R. Colucci, L. Antonioli, O. Awwad, C. Ugolini, and M. Tuccori, “Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: characterization of molecular mechanisms,” Pharmacological Research, vol. 63, no. 1, pp. 59–67, 2010. View at Google Scholar
  6. G. H. Heeba, M. E. Mahmoud, and A. A. Hanafy, “Anti-inflammatory potential of curcumin and quercetin in rats: role of oxidative stress, heme oxygenase-1 and TNF-α,” Toxicology & Industrial Health, vol. 30, no. 6, pp. 551–560, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Arpana, D. Bagyaraj, E. Prakasa, T. Parameswaran, and B. Rahiman, “Symbiotic response of patchouli Pogostemon cablin (Blanco) Benth. to different arbuscular mycorrhizal fungi,” Advances in Environmental Biology, vol. 2, no. 1, pp. 20–24, 2008. View at Google Scholar
  8. M. K. Swamy and U. R. Sinniah, “Patchouli (Pogostemon cablin Benth.): botany, agrotechnology and biotechnological aspects,” Industrial Crops and Products, vol. 87, pp. 161–176, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Najafian, “Storage conditions affect the essential oil composition of cultivated balm mint herb (Lamiaceae) in Iran,” Industrial Crops and Products, vol. 52, no. 52, pp. 575–581, 2014. View at Google Scholar
  10. A. Santana, A. Uetenabaro, T. Silva, L. Costa, and R. Oliveira, “Storage conditions of Ocimum gratissimum L. leaves influence the quality of essential oil,” Journal of Essential Oil Research, vol. 29, pp. 1–8, 2016. View at Google Scholar
  11. Z. Z. Zhang, X. Y. Chen, H. B. Chen, L. Wang, and J. L. Liang, “Anti-inflammatory activity of β-patchoulene isolated from patchouli oil in mice,” European Journal of Pharmacology, vol. 781, pp. 229–238, 2016. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Y. He, Q. C. Liu, W. Peng, Y. L. Huang, and C. J. Wu, “Bioactivities and serum pharmacochemistry of Qi-Wei-Xiao-Yan-Tang,” Pharmaceutical Biology, vol. 51, no. 5, pp. 629–634, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. L. Zhang, J. J. Hu, J. W. Lin, W. S. Fang, and G. H. Du, “Anti-inflammatory and analgesic effects of ethanol and aqueous extracts of pterocephalus hookeri (C.B. Clarke) Hoeck,” Journal of Ethnopharmacology, vol. 123, no. 3, pp. 510–514, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. J. S. Deng, S. S. Huang, T. H. Lin, M. M. Lee, and C. C. Kuo, “Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice,” Journal of Agricultural & Food Chemistry, vol. 61, no. 21, pp. 5064–5071, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Buchi and W. D. Macleod, “Synthesis of patchouli alcohol,” Journal of the American Chemical Society, vol. 84, pp. 3205-3206, 1962. View at Publisher · View at Google Scholar
  16. G. Büchi, R. E. Erickson, and N. Wakabayashi, “Terpenes. XVI.1,2 constitution of patchouli alcohol and absolute configuration of cedrene,” Journal of the American Chemical Society, vol. 83, no. 4, pp. 927–938, 2002. View at Google Scholar
  17. G. Buchi, W. D. Macleod, and J. Padilla, “Terpenes. XIX.1 Synthesis of patchouli alcohol2,” Journal of the American Chemical Society, vol. 86, no. 20, pp. 188–191, 2002. View at Google Scholar
  18. J. R. Vane and R. M. Botting, “New insights into the mode of action of anti-inflammatory drugs,” Inflammation Research, vol. 44, no. 1, pp. 1–10, 1995. View at Publisher · View at Google Scholar · View at Scopus
  19. J. C. Zanini, Y. S. Medeiros, A. B. Cruz, R. Yunes, and J. B. Calixto, “Action of compounds from Mandevilla velutina on croton oil-induced ear oedema in mice. A comparative study with steroidal and nonsteroidal antiinflammatory drugs,” Phytotherapy Research, vol. 6, no. 1, pp. 1–5, 1992. View at Publisher · View at Google Scholar · View at Scopus
  20. S. J. Wang, Y. Tong, S. Lu, R. Yang, X. Liao, and Y. F. Xu, “Anti-inflammatory activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves,” Planta Medica, vol. 76, no. 14, pp. 1492–1496, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. C. N. Lu, Z. G. Yuan, X. L. Zhang, R. Yan, Y. Q. Zhao, and M. Liao, “Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway,” International Immunopharmacology, vol. 14, no. 1, pp. 121–126, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. J. J. Cheng, M. A. Ting-Yun, W. Liu, H. X. Wang, J. Z. Jiang, and Y. Wei, “In vivo evaluation of the anti-inflammatory and analgesic activities of compound Muniziqi granule in experimental animal models,” BMC Complementary & Alternative Medicine, vol. 16, no. 1, pp. 1–10, 2015. View at Google Scholar
  23. M. Mansouri, A. A. Taghi, B. Hemmati, S. Naghizadeh, A. Mard, and A. Rezaie, “A study of the mechanism underlying the anti-inflammatory effect of ellagic acid in carrageenan-induced paw edema in rats,” Indian Journal of Pharmacology, vol. 47, no. 3, pp. 292–298, 2015. View at Publisher · View at Google Scholar · View at Scopus
  24. C. E. Juge-Aubry, E. Somm, R. Chicheportiche, D. Burger, A. Pernin, and B. Cuénod-Pittet, “Regulatory effects of interleukin (IL)-1, interferon-beta, and IL-4 on the production of IL-1 receptor antagonist by human adipose tissue,” Journal of Clinical Endocrinology & Metabolism, vol. 89, no. 6, pp. 2652–2658, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. H. R. Kim, Y. S. Da, and K. H. Chung, “In vitro inflammatory effects of polyhexamethylene biguanide through NF-κB activation in A549 cells,” Toxicology in Vitro, vol. 38, pp. 1–7, 2016. View at Google Scholar
  26. K. Y. De, B. Thillayegoldenberg, M. C. Naud, C. A. Da, C. Auriault, and C. Verwaerde, “Inhibition of experimental autoimmune uveoretinitis by systemic and subconjunctival adenovirus-mediated transfer of the viral IL-10 gene,” Clinical & Experimental Immunology, vol. 130, pp. 212–223, 2002. View at Google Scholar
  27. N. Subramanian and M. A. Bray, “Interleukin 1 releases histamine from human basophils and mast cells in vitro,” Journal of Immunology, vol. 138, no. 2, pp. 271–275, 1987. View at Google Scholar
  28. D. Salvemini, S. L. Settle, J. L. Masferrer, K. Seibert, M. G. Currie, and P. Needleman, “Regulation of prostaglandin production by nitric oxide; an in vivo analysis,” British Journal of Pharmacology, vol. 114, no. 6, pp. 1171–1178, 1995. View at Publisher · View at Google Scholar · View at Scopus
  29. N. Paulino, A. S. Paulino, S. N. Diniz, S. D. Mendonça, I. D. Gonçalves, and F. F. Flores, “Evaluation of the anti-inflammatory action of curcumin analog (DM1): effect on iNOS and COX-2 gene expression and autophagy pathways,” Bioorganic & Medicinal Chemistry, vol. 24, no. 8, pp. 1927–1935, 2016. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Claoué-Long and C. Edgoose, “NF-B family of transcription factors: central regulators of innate and adaptive immune functions,” Clinical Microbiology Reviews, vol. 15, no. 3, pp. 414–429, 2002. View at Google Scholar
  31. P. Bamborough, J. F. Callahan, J. A. Christopher, J. K. Kerns, J. Liddle, and D. D. Miller, “Progress towards the development of anti-inflammatory inhibitors of IKKbeta,” Current Topics in Medicinal Chemistry, vol. 9, no. 7, pp. 623–639, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Adli, E. Merkhofer, P. Cogswell, and A. S. Baldwin, “IKKa and IKKb each function to regulate NF-κB activation in the TNF-induced/canonical pathway,” PloS One, vol. 5, no. 2, p. 178, 2010. View at Google Scholar
  33. C. J. Hunter and I. Plaen, “Inflammatory signaling in NEC: role of NF-κB, cytokines and other inflammatory mediators,” Pathophysiology, vol. 21, no. 1, pp. 55–65, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. K. M. Sakthivel and C. Guruvayoorappan, “Acacia ferruginea inhibits inflammation by regulating inflammatory iNOS and COX-2,” Journal of Immunotoxicology, vol. 13, no. 1, pp. 1–9, 2015. View at Google Scholar