The Astrocytic S100B Protein with Its Receptor RAGE Is Aberrantly Expressed in SOD1<sup>G93A</sup> Models, and Its Inhibition Decreases the Expression of Proinflammatory Genes

<div>S100B increase in GFAP-positive cells in the lumbar spinal cord from SOD1<sup>G93A</sup> rats. Double immunofluorescence labelling was performed with anti-S100B (green) and anti-GFAP (red) in the lumbar spinal cord from wild-type (WT), presymptomatic (ps-SOD1<sup>G93A</sup>), and end-stage (es-SOD1<sup>G93A</sup>) rats. The images were acquired from the grey matter (GM) and from the white matter (WM) at two magnifications (scale bars: 50 <i>μ</i>m left columns and 20 <i>μ</i>m right column). Merged panels also show To-Pro-3 nuclear staining (TP3, blue). In WM from WT rats, insets show a double immunolabelling with anti-S100B (green) and anti-CNPase (red) and merged inset also with To-Pro-3 staining (scale bar: 10 <i>μ</i>m).</div>

Mediators of Inflammation

fig1

Figure 1

Figure 1: The Astrocytic S100B Protein with Its Receptor RAGE Is Aberrantly Expressed in SOD1<sup>G93A</sup> Models, and Its Inhibition Decreases the Expression of Proinflammatory Genes 

Figure 1 | The Astrocytic S100B Protein with Its Receptor RAGE Is Aberrantly Expressed in SOD1G93A Models, and Its Inhibition Decreases the Expression of Proinflammatory Genes 