The Astrocytic S100B Protein with Its Receptor RAGE Is Aberrantly Expressed in SOD1<sup>G93A</sup> Models, and Its Inhibition Decreases the Expression of Proinflammatory Genes

<div>RAGE increase in GFAP-positive cells in the lumbar spinal cord from SOD1<sup>G93A</sup> rats. Double immunofluorescence was performed with anti-RAGE (red) and anti-GFAP (green) on lumbar spinal cord from wild-type (WT), presymptomatic (ps-SOD1<sup>G93A</sup>), and end-stage (es-SOD1<sup>G93A</sup>) rats. The images were acquired from grey (GM) and white matter (WM) at two magnifications (scale bars: 50 <i>μ</i>m left column and 20 <i>μ</i>m right column). Merged panels also show To-Pro-3 nuclear staining (TP3, blue). In GM from WT rats, insets show a double immunofluorescence with anti-RAGE (red) and anti-ChAT (green) (scale bar: 10 <i>μ</i>m).</div>

Mediators of Inflammation

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Figure 2: The Astrocytic S100B Protein with Its Receptor RAGE Is Aberrantly Expressed in SOD1<sup>G93A</sup> Models, and Its Inhibition Decreases the Expression of Proinflammatory Genes 

Figure 2 | The Astrocytic S100B Protein with Its Receptor RAGE Is Aberrantly Expressed in SOD1G93A Models, and Its Inhibition Decreases the Expression of Proinflammatory Genes 