Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects

Table 1

Subject characteristics.

	Exposed					Unexposed
	No fibrosis		Asbestosis			Healthy controls
N	66		19			28
Age (years)	64.5	(6.2)	68.5	(6.0)		62.2	(6.6)
Time since the beginning of the exposure (years)	43.6	(0.9)	46.2	(3.4)
FVC (% pred)	88.8	(15.6)	83.7	(10.8)		99.5	(10.8)
FEV1 (% pred)	88.5	(14.2)	81.8	(12.0)		96.7	(11.6)
DL,CO (% pred)	106.4	(17.4)	87.1	(16.8)		N.A.
IL-6 (pg/ml)	3.2	(2.4–4.3)	3.2	(2.0–5.0)		2.1	(1.6–2.8)
CRP (μg/ml)	0.93	(0.37–1.99	1.20	(0.60–2.94)		0.47	(0.27–1.00)
Adipsin (ng/ml)	893	(777–1069)	1022	(950–1224)		908	(757–1045)
MMP-9 (ng/ml)	28.1	(22.4–36.9)	54.7	(32.8–70.9)		30.3	(25.4–38.9)

Values are presented as mean (SD) or median (IQR) when appropriate according to the distribution of variables. FVC: forced vital capacity; FEV₁: forced expiratory volume in 1 second; D_L,CO: diffusing capacity for carbon monoxide; IL-6: interleukin 6; CRP: C-reactive protein; MMP-9: matrix metalloproteinase-9; N.A: not assessed. values were calculated between asbestos-exposed subjects without fibrosis and asbestos-exposed subjects with asbestosis using unpaired t-test or Mann–Whitney U test when appropriate.