Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases

Figure 1

The 5-LO pathway: biosynthesis, signaling, and effect on cardiovascular system. 5-Lipoxygenase (5-LO), leukotriene (LT), cytosolic phospholipase A2 (cPLA₂), arachidonic acid (AA), 5-LO-activating protein (FLAP), multidrug resistance protein-1 (MRP1), endothelial cells (ECs), and smooth muscle cells (SMCs).