Maresin 1 Mitigates High Glucose-Induced Mouse Glomerular Mesangial Cell Injury by Inhibiting Inflammation and Fibrosis

Figure 7

The expression of TGF-β1 and FN in each group. (a) Expression of TGF-β1 in GMCs which were treated with different does of maresin 1 for 30 min and were exposed to high glucose (30 mmol/L) for 48 h. Compared with NC group, expression of TGF-β1 was significantly increased in HG group, and compared with HG group, expression of TGF-β1 was significantly lower in M + HG group, and there were effective changes in M2 + HG group. (b) The corresponding relative gray value statistics graph of the mRNA level. versus NC group, versus HG group. (c) FN ELISA kit detected the level of FN in each supernatant of GMCs; we detected the similar change with TGF-β1; versus NC group, versus HG group.

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