The Clinical Significance of Increased Serum Proinflammatory Cytokines, C-Reactive Protein, and Erythrocyte Sedimentation Rate in Patients with Hidradenitis Suppurativa

Table 6

Comparison of inflammatory serum marker levels among healthy controls and patients with hidradenitis suppurativa according to Hurley staging system.

Cytokine levels (pg mL^−1); CRP (mg L^−1); ESR (mm hour^−1), mean ± SD (median)
	Healthy controls	Stage I	Stage II	Stage III	value^a
IL-1β	0.4 ± 0.8 (0.13)	0.6 ± 1.7 (0.00)	1.2 ± 3.5 (0.00)	0.4 ± 0.7 (0.09)	0.489
IL-6	0.6 ± 1.3 (0.00)	2.5 ± 5.2 (0.00)	3.3 ± 4.5 (2.07)	17.3 ± 17.5 (10.65)	<0.001
IL-8	36.3 ± 73.9 (12.60)	8.8 ± 12.9 (6.20)	23.2 ± 52.8 (14.02)	54.8 ± 95.5 (27.97)	0.023
IL-10	3.3 ± 5.8 (0.97)	0.5 ± 0.4 (0.41)	3.6 ± 10.6 (0.76)	5.0 ± 7.9 (2.05)	0.157
IL-12p70	0.6 ± 1.9 (0.01)	0.3 ± 0.7 (0.00)	5.1 ± 15.0 (0.00)	1.7 ± 2.5 (0.68)	0.281
IL-17A	0.3 ± 0.6 (0.00)	0.7 ± 2.2 (0.00)	6.9 ± 15.5 (0.00)	5.1 ± 6.1 (1.79)	0.073
IL-22	0.0 ± 0.1 (0.00)	0.0 ± 0.0 (0.00)	11.2 ± 28.9 (0.00)	7.6 ± 23.1 (0.00)	0.360
IL-23	1.0 ± 2.5 (0.09)	0.1 ± 0.3 (0.00)	1.2 ± 4.5 (0.00)	0.3 ± 0.6 (0.00)	0.071
sTNF-RI	325.9 ± 507.1 (145.81)	649.9 ± 360.9 (724.17)	595.1 ± 599.2 (401.47)	1874.2 ± 3912.4 (641.13)	<0.001
sTNF-RII	527.4 ± 266.9 (438.65)	412.3 ± 322.4 (353.40)	947.2 ± 610.2 (814.01)	1225.5 ± 1019.4 (890.28)	0.001
CRP	1.2 ± 2.1 (0.55)	5.6 ± 7.2 (2.00)	8.3 ± 9.2 (5.00)	33.6 ± 30.8 (22.50)	<0.001
ESR	10.2 ± 5.5 (9.50)	17.9 ± 12.9 (19.00)	20.8 ± 13.0 (21.00)	62.9 ± 25.0 (55.50)	<0.001

IL: interleukin; CRP: C-reactive protein; sTNF-RI: soluble TNF receptor I; sTNF-RII: soluble TNF receptor II; ESR: level erythrocyte sedimentation rate. ^aKruskal-Wallis test comparing the circulating levels of inflammatory cytokines among the healthy controls and patients with hidradenitis suppurativa according to Hurley staging system. .