Statins Reduce Lipopolysaccharide-Induced Cytokine and Inflammatory Mediator Release in an In Vitro Model of Microglial-Like Cells

Figure 2

Statin-induced changes in (a) IL-1β, (b) TNF-α, and (c) PGE2 release in LPS-activated dTHP-1 cells. Cells were pretreated for 24 h with one of the six statins (0–100 μM) prior to receiving a 24 h LPS stimuli, after which time IL-1β, TNF-α, and PGE2 release were quantified by ELISA. Control cells represent cells treated with statin and LPS vehicles. Data shown is mean + SD of four independent experiments; vehicle control (0 μM) is represented as mean + SEM. Statin treatment versus LPS only.

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