Mediators of Inflammation / 2017 / Article / Fig 1

Research Article

A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation

Figure 1

Carbon tetrachloride liver injury progression in WT and CD154KO mice. (a) Relative levels of CD40 mRNA expression (arbitrary units) in the liver of WT and CD154KO mice at time 0 and after 3 and 9 intraperitoneal CCl4 injections (mean ± SD, ). Representative HE-stained liver tissue sections of WT and CD154KO mice at time 0 (b) and after 1 (c), 2 (d), 3 (e), and 9 (f) intraperitoneal CCl4 injections (inj.). Top panels, low magnifications (scale bar 500 μm); bottom panels, high magnifications (scale bar 100 μm); ( at time 0, at 1 injection, at 2 injections, at 3 injections, and at 9 injections for each group of mice). (g) WT and CD154KO mice show similar hepatic cytolytic response after CCl4 administration. Serum measurements of albumin (gL), bilirubin (μmol/L), and liver enzymes (IU/L) after 1 CCl4 injection in WT and CD154KO mice (mean ± SD, ).
(a)
(b)
(c)
(d)
(e)
(f)
(g)