A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation
Carbon tetrachloride liver injury progression in WT and CD154KO mice. (a) Relative levels of CD40 mRNA expression (arbitrary units) in the liver of WT and CD154KO mice at time 0 and after 3 and 9 intraperitoneal CCl4 injections (mean ± SD, ). Representative HE-stained liver tissue sections of WT and CD154KO mice at time 0 (b) and after 1 (c), 2 (d), 3 (e), and 9 (f) intraperitoneal CCl4 injections (inj.). Top panels, low magnifications (scale bar 500 μm); bottom panels, high magnifications (scale bar 100 μm); ( at time 0, at 1 injection, at 2 injections, at 3 injections, and at 9 injections for each group of mice). (g) WT and CD154KO mice show similar hepatic cytolytic response after CCl4 administration. Serum measurements of albumin (gL), bilirubin (μmol/L), and liver enzymes (IU/L) after 1 CCl4 injection in WT and CD154KO mice (mean ± SD, ).