Mediators of Inflammation / 2017 / Article / Fig 4

Review Article

Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNFα

Figure 4

Potential mechanisms by which TNFα and its receptors TNFR1 and TNFR2 contribute to the neuropathology in ALS. Both neuroprotective and neurotoxic functions are proposed for TNFR1 and TNFR2, depending on the cell type involved.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.