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Mediators of Inflammation
Volume 2017, Article ID 3090782, 12 pages
https://doi.org/10.1155/2017/3090782
Research Article

Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 Receptor on Mast Cells

1Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, China
2The PLA Center of Respiratory and Allergic Disease Diagnosing Management, General Hospital of Shenyang Military Area Command, Shenyang 110840, China
3Department of Dermatology, Donggang Center Hospital, Donggang, Liaoning 118300, China

Correspondence should be addressed to Shaoheng He; moc.liamtoh@ehgnehaohs

Received 30 December 2016; Revised 18 April 2017; Accepted 11 May 2017; Published 3 August 2017

Academic Editor: Alex Kleinjan

Copyright © 2017 Yalin Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Chang, C. L. Keen, and M. E. Gershwin, “Treatment of eczema,” Clinical Reviews in Allergy & Immunology, vol. 33, no. 3, pp. 204–225, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Fatima, A. Rafiq, and Z. Majid, “Harlequin ichthyosis in an infant born to a father with eczema,” Journal of Tropical Pediatrics, vol. 61, no. 2, pp. 143–145, 2015. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Novak, S. Kruse, J. Potreck et al., “Single nucleotide polymorphisms of the IL18 gene are associated with atopic eczema,” The Journal of Allergy and Clinical Immunology, vol. 115, no. 4, pp. 828–833, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. D. Wang, M. Drenker, B. Eiz‐Vesper, T. Werfel, and M. Wittmann, “Evidence for a pathogenetic role of interleukin-18 in cutaneous lupus erythematosus,” Arthritis and Rheumatism, vol. 58, no. 10, pp. 3205–3215, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Companjen, L. van der Wel, L. van der Fits, J. Laman, and E. Prens, “Elevated interleukin-18 protein expression in early active and progressive plaque-type psoriatic lesions,” European Cytokine Network, vol. 15, no. 3, pp. 210–216, 2004. View at Google Scholar
  6. N. Higashi, B. Gesser, S. Kawana, and K. Thestrup-Pedersen, “Expression of IL-18 mRNA and secretion of IL-18 are reduced in monocytes from patients with atopic dermatitis,” The Journal of Allergy and Clinical Immunology, vol. 108, no. 4, pp. 607–614, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Gutzmer, K. Langer, S. Mommert, M. Wittmann, A. Kapp, and T. Werfel, “Human dendritic cells express the IL-18R and are chemoattracted to IL-18,” Journal of Immunology, vol. 171, no. 12, pp. 6363–6371, 2003. View at Publisher · View at Google Scholar
  8. S. M. Naik, G. Cannon, G. J. Burbach et al., “Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene,” The Journal of Investigative Dermatology, vol. 113, no. 5, pp. 766–772, 1999. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Akira, “The role of IL-18 in innate immunity,” Current Opinion in Immunology, vol. 12, no. 1, pp. 59–63, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Nakanishi, T. Yoshimoto, H. Tsutsui, and H. Okamura, “Interleukin-18 regulates both Th1 and Th2 responses,” Annual Review of Immunology, vol. 19, pp. 423–474, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Xu, W. L. Chan, B. P. Leung et al., “Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells,” The Journal of Experimental Medicine, vol. 188, no. 8, pp. 1485–1492, 1998. View at Publisher · View at Google Scholar · View at Scopus
  12. J. E. Sims and D. E. Smith, “The IL-1 family: regulators of immunity,” Nature Reviews Immunology, vol. 10, no. 2, pp. 89–102, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Wittmann, R. Purwar, C. Hartmann, R. Gutzmer, and T. Werfel, “Human keratinocytes respond to interleukin-18: implication for the course of chronic inflammatory skin diseases,” The Journal of Investigative Dermatology, vol. 124, no. 6, pp. 1225–1233, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Novick, S. H. Kim, G. Fantuzzi, L. L. Reznikov, C. A. Dinarello, and M. Rubinstein, “Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response,” Immunity, vol. 10, no. 1, pp. 127–136, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Girard, J. Rech, M. Brown et al., “Elevated serum levels of free interleukin-18 in adult-onset Still’s disease,” Rheumatology (Oxford), vol. 55, no. 12, pp. 2237–2247, 2016. View at Publisher · View at Google Scholar
  16. A. Bretterklieber, C. Beham‐Schmid, G. J. Sturm et al., “Anaphylaxis with clonal mast cells in normal looking skin - a new entity?” Allergy, vol. 70, no. 7, pp. 864–872, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Ando, K. Matsumoto, S. Namiranian et al., “Mast cells are required for full expression of allergen/SEB-induced skin inflammation,” The Journal of Investigative Dermatology, vol. 133, no. 12, pp. 2695–2705, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Ribbing, C. Engblom, J. Lappalainen et al., “Mast cells generated from patients with atopic eczema have enhanced levels of granule mediators and an impaired Dectin-1 expression,” Allergy, vol. 66, no. 1, pp. 110–119, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Lange, E. Rietschel, N. Hunzelmann, and K. Hartmann, “Elevated levels of tryptase in children with nummular eczema,” Allergy, vol. 63, no. 7, pp. 947–949, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Schultz Larsen and J. M. Hanifin, “Secular change in the occurrence of atopic dermatitis,” Acta Dermato-Venereologica Supplementum, vol. 176, pp. 7–12, 1992. View at Google Scholar
  21. P. A. Dewan, H. C. Tieu, and B. S. Chieng, “Phimosis: is circumcision necessary?” Journal of Paediatrics and Child Health, vol. 32, no. 4, pp. 285–289, 1996. View at Publisher · View at Google Scholar
  22. H. Jin, R. He, M. Oyoshi, and R. S. Geha, “Animal models of atopic dermatitis,” The Journal of Investigative Dermatology, vol. 129, no. 1, pp. 31–40, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. S. He, M. D. Gaca, and A. F. Walls, “A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase,” The Journal of Pharmacology and Experimental Therapeutics, vol. 286, no. 1, pp. 289–297, 1998. View at Google Scholar
  24. J. Vom Berg, M. Vrohlings, S. Haller et al., “Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection,” The Journal of Experimental Medicine, vol. 210, no. 13, pp. 2803–2811, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Akabane, K. Matsuzaki, S. I. Yamashita et al., “Constitutive activation of PINK1 protein leads to proteasome-mediated and non-apoptotic cell death independently of mitochondrial autophagy,” The Journal of Biological Chemistry, vol. 291, no. 31, pp. 16162–16174, 2016. View at Publisher · View at Google Scholar · View at Scopus
  26. S. He, H. Zhang, H. Chen et al., “Expression and release of IL-29 by mast cells and modulation of mast cell behavior by IL-29,” Allergy, vol. 65, no. 10, pp. 1234–1241, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Zhang, X. Yang, H. Yang et al., “Modulation of mast cell proteinase-activated receptor expression and IL-4 release by IL-12,” Immunology and Cell Biology, vol. 85, no. 7, pp. 558–566, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. D. Novick, B. Schwartsburd, R. Pinkus et al., “A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18,” Cytokine, vol. 14, no. 6, pp. 334–342, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. L. P. Shek, A. R. Chong, S. E. Soh et al., “Specific profiles of house dust mite sensitization in children with asthma and in children with eczema,” Pediatric Allergy and Immunology, vol. 21, no. 4, Part 2, pp. e718–e722, 2010. View at Google Scholar
  30. J. R. Metcalfe, N. D’Vaz, M. Makrides et al., “Elevated IL-5 and IL-13 responses to egg proteins predate the introduction of egg in solid foods in infants with eczema,” Clinical and Experimental Allergy, vol. 46, no. 2, pp. 308–316, 2016. View at Publisher · View at Google Scholar · View at Scopus
  31. S. T. Leach, I. Messina, D. A. Lemberg, D. Novick, M. Rubenstein, and A. S. Day, “Local and systemic interleukin-18 and interleukin-18-binding protein in children with inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 14, no. 1, pp. 68–74, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. X. T. Shao, L. Feng, L. J. Gu et al., “Expression of interleukin-18, IL-18BP, and IL-18R in serum, synovial fluid, and synovial tissue in patients with rheumatoid arthritis,” Clinical and Experimental Medicine, vol. 9, no. 3, pp. 215–221, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. P. Migliorini, C. Anzilotti, F. Pratesi et al., “Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus,” European Cytokine Network, vol. 21, no. 4, pp. 264–271, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. W. P. Arend, G. Palmer, and C. Gabay, “IL-1, IL-18, and IL-33 families of cytokines,” Immunological Reviews, vol. 223, pp. 20–38, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Wittmann, A. Macdonald, and J. Renne, “IL-18 and skin inflammation,” Autoimmunity Reviews, vol. 9, no. 1, pp. 45–48, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. T. Yoshimoto, H. Mizutani, H. Tsutsui et al., “IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6,” Nature Immunology, vol. 1, no. 2, pp. 132–137, 2000. View at Publisher · View at Google Scholar
  37. T. Yoshimoto, H. Tsutsui, K. Tominaga et al., “IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 24, pp. 13962–13966, 1999. View at Google Scholar
  38. T. Hoshino, H. Yagita, J. R. Ortaldo, R. H. Wiltrout, and H. A. Young, “In vivo administration of IL-18 can induce IgE production through Th2 cytokine induction and up-regulation of CD40 ligand (CD154) expression on CD4+ T cells,” European Journal of Immunology, vol. 30, no. 7, pp. 1998–2006, 2000. View at Publisher · View at Google Scholar
  39. H. Konishi, H. Tsutsui, T. Murakami et al., “IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 17, pp. 11340–11345, 2002. View at Google Scholar
  40. S. M. Lind, C. Kuylenstierna, M. Moll et al., “IL-18 skews the invariant NKT-cell population via autoreactive activation in atopic eczema,” European Journal of Immunology, vol. 39, no. 8, pp. 2293–2301, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Zhan, W. Zheng, Q. Jiang et al., “Upregulated expression of substance P (SP) and NK1R in eczema and SP induced mast cell accumulation,” Cell Biology and Toxicology, 2016, In press. View at Google Scholar
  42. S. He, M. D. Gaça, M. E. AR, and A. F. Walls, “Inhibitors of chymase as mast cell-stabilizing agents: contribution of chymase in the activation of human mast cells,” The Journal of Pharmacology and Experimental Therapeutics, vol. 291, no. 2, pp. 517–523, 1999. View at Google Scholar
  43. H. Tsutsui, H. Mizutani, and K. Nakanishi, “Contribution of interleukin 18 to the development of infection-associated atopic dermatitis,” Current Problems in Dermatology, vol. 41, pp. 93–103, 2011. View at Google Scholar
  44. M. Wittmann, R. Doble, M. Bachmann, J. Pfeilschifter, T. Werfel, and H. Mühl, “IL-27 regulates IL-18 binding protein in skin resident cells,” PLoS One, vol. 7, no. 6, article e38751, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. Y. Kannan, J. Yu, R. M. Raices et al., “IkappaBzeta augments IL-12- and IL-18-mediated IFN-gamma production in human NK cells,” Blood, vol. 117, no. 10, pp. 2855–2863, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. J. Paulukat, M. Bosmann, M. Nold et al., “Expression and release of IL-18 binding protein in response to IFN-gamma,” Journal of Immunology, vol. 167, no. 12, pp. 7038–7043, 2001. View at Publisher · View at Google Scholar
  47. K. G. Veenstra, Z. L. Jonak, S. Trulli, and J. A. Gollob, “IL-12 induces monocyte IL-18 binding protein expression via IFN-gamma,” Journal of Immunology, vol. 168, no. 5, pp. 2282–2287, 2002. View at Publisher · View at Google Scholar
  48. G. Sellge, M. Barkowsky, S. Kramer et al., “Interferon-gamma regulates growth and controls Fcgamma receptor expression and activation in human intestinal mast cells,” BMC Immunology, vol. 15, p. 27, 2014. View at Publisher · View at Google Scholar · View at Scopus