The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression
The impact of parenteral Vit C treatment on the 72-hour survival rate of septic mice and sepsis-induced MODS. The 72-hour survival rate of WT mice and Gulo−/− mice was improved on administration of 200 mg/Kg parenteral Vit C twice after CLP (a). Parenteral Vit C improved the biomarkers of liver (b and c), renal (d), respiratory (e and f), and circulatory (g) function in CLP-exposed WT mice and Vit C deficient Gulo−/− mice. The survival rate was analyzed by Kaplan-Meier via the log-rank test, per group. WT (CLP) versus WT (CLP + Vit C), . Gulo−/− (CLP) versus Gulo−/− (CLP + Vit C), . WT (CLP) versus Gulo−/− (CLP), . Data were represented as mean ± standard deviation (SD) and analyzed by software SPSS 17.0 with one-way ANOVA, per group, or .