Mediators of Inflammation / 2017 / Article / Fig 3

Research Article

The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression

Figure 3

The impact of parenteral Vit C on the immunosuppressive function of CD4+CD25+ Tregs. The parenteral Vit C inhibited the immunosuppressive function of CD4+CD25+ Tregs which upregulated the proliferative response (a) and release of IFN-γ (c) but significantly downregulated the apoptotic rate (b) and release of IL-4 (d) of splenic conventional CD4+CD25 T cells. Data were represented as mean ± standard deviation (SD) and analyzed by software SPSS 17.0 with one-way ANOVA, per group, or .