Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis

Figure 1

Lymphocyte source of intracellular granzymes A and B in peritoneal lavage fluid (PLF) and blood of wild-type mice before and after intraperitoneal infection with E. coli. Mice were infected intraperitoneally with CFU E. coli and sacrificed before and at 6, 14, and 20 h after infection. To show the lymphocyte source of each granzyme, the total gzmA- or gzmB-positive cells were selected and, the lymphocyte subsets to which those gzm-expressing cells belong, identified. (a) and (c) show the percentage of the total gzmA and (b) and (d) of gzmB expressed by different lymphocyte subsets from PLF ((a) and (b)) and blood ((c) and (d)) are shown. Data are box-and-whisker diagrams depicting the smallest observation, lower quartile, median, upper quartile, and largest observation.  = 5-6 at each time point.

(a)

(b)

(c)

(d)