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Mediators of Inflammation
Volume 2017, Article ID 4256352, 9 pages
Review Article

Liver Regeneration: Analysis of the Main Relevant Signaling Molecules

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China

Correspondence should be addressed to Hong Tang; moc.liamtoh@8916gnath

Received 12 May 2017; Revised 19 July 2017; Accepted 10 August 2017; Published 30 August 2017

Academic Editor: Hua Wang

Copyright © 2017 Yachao Tao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Liver regeneration is a highly organized tissue regrowth process and is the most important reaction of the liver to injury. The overall process of liver regeneration includes three phases: priming stage, proliferative phase, and termination phase. The initial step aims to induce hepatocytes to be sensitive to growth factors with the aid of some cytokines, including TNF-α and IL-6. The proliferation phase promotes hepatocytes to re-enter G1 with the stimulation of growth factors. While during the termination stage, hepatocytes will discontinue to proliferate to maintain normal liver mass and function. Except for cytokine- and growth factor-mediated pathways involved in regulating liver regeneration, new substances and technologies emerge to influence the regenerative process. Here, we reviewed novel and important signaling molecules involved in the process of liver regeneration to provide a cue for further research.