Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori Infection

Figure 2

The imbalance of type 1 cytokine/type 2 cytokine expression was also introduced by H. pylori infection in vitro and in vivo. (a) After coculture for 48 hours, the concentration of IL-4, IL-5, and IL-13 in supernatants was increased in the H. pylori intervention group, while the expressions of IFN-γ reduced. (b) After successful establishment of an H. pylori-infected model, the concentration of IL-4, IL-5, and IL-13 was enhanced in gastric homogenate from mice treated with H. pylori strains; however, IFN-γ in plasma was inhibited, when compared to that in the normal group. Moreover, the East Asian type evoked the most significant change. , , and .

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