Group 2 Innate Lymphoid Cells Are Involved in Skewed Type 2 Immunity of Gastric Diseases Induced by Helicobacter pylori Infection
GATA-3 was enhanced in lymphocytes isolated from H. pylori+ gastric cancer tissues, which was responsible for the skewed type 2 immune response. As shown in the immunohistochemical staining, when compared to the H. pylori− gastric cancer tissues (a), GATA-3 expression was significantly upregulated in the interstitial tissues of H. pylori+ gastric cancer tissues (b). Moreover, the GATA-3+ cell indicated a morphological characteristic of lymphocyte. (c, d) Tumor-infiltrating lymphocytes from H. pylori+ gastric cancer tissues (Hp+) showed a stronger secretion of IL-4 but a weaker secretion of IFN-γ, when compared to those from H. pylori− gastric cancer tissues (Hp−). (e–i) After preparation of mononuclear cells from gastric tissues, GATA-3+ population was found to increase in H. pylori+ gastric cancer tissues by flow cytometry. Moreover, Lin−GATA-3+ population and Lin+GATA-3+ population were increased in cells from H. pylori+ gastric cancer tissues, respectively. , .
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