Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2017, Article ID 5108525, 5 pages
https://doi.org/10.1155/2017/5108525
Review Article

TM4SF5-Mediated Roles in the Development of Fibrotic Phenotypes

Department of Pharmacy, Research Institute of Pharmaceutical Sciences, Tumor Microenvironment Global Core Research Center, Medicinal Bioconvergence Research Center, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea

Correspondence should be addressed to Jung Weon Lee; rk.ca.uns@lwj

Received 20 February 2017; Accepted 13 March 2017; Published 26 March 2017

Academic Editor: Pilar Sandoval

Copyright © 2017 Jihye Ryu and Jung Weon Lee. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Yanez-Mo, O. Barreiro, M. Gordon-Alonso, M. Sala-Valdes, and F. Sanchez-Madrid, “Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes,” Trends in Cell Biology, vol. 19, no. 9, pp. 434–446, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. S. A. Lee, K. H. Park, and J. W. Lee, “Modulation of signaling between TM4SF5 and integrins in tumor microenvironment,” Frontiers in Bioscience, vol. 16, no. 5, pp. 1752–1758, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Detchokul, E. D. Williams, M. W. Parker, and A. G. Frauman, “Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies,” British Journal of Pharmacology, vol. 171, no. 24, pp. 5462–5490, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. M. D. Wright, J. Ni, and G. B. Rudy, “The L6 membrane proteins—a new four-transmembrane superfamily,” Protein Science, vol. 9, no. 8, pp. 1594–1600, 2000. View at Publisher · View at Google Scholar
  5. S. Veenbergen and A. B. van Spriel, “Tetraspanins in the immune response against cancer,” Immunology Letters, vol. 138, no. 2, pp. 129–136, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. H. J. Kim, S. Kwon, S. H. Nam et al., “Dynamic and coordinated single-molecular interactions at TM4SF5-enriched microdomains guide invasive behaviors in 2- and 3-dimensional environments,” The FASEB Journal, 2017. View at Publisher · View at Google Scholar
  7. D. Lee, J. Na, J. Ryu et al., “Interaction of tetraspan (in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells,” Hepatology, vol. 61, no. 6, pp. 1978–1997, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. S. A. Lee, H. W. Ryu, Y. M. Kim et al., “Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative,” Hepatology, vol. 49, no. 4, pp. 1316–1325, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Kang, J. Ryu, D. Lee et al., “Correlations between transmembrane 4 L6 family member 5 (TM4SF5), CD151, and CD63 in liver fibrotic phenotypes and hepatic migration and invasive capacities,” PLoS One, vol. 9, no. 7, p. e102817, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. S. A. Lee, T. Y. Kim, T. K. Kwak et al., “Transmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasis,” Journal of Cellular Biochemistry, vol. 111, no. 1, pp. 59–66, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Choi, S.-A. Lee, T. K. Kwak et al., “Cooperation between integrin α5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity,” Blood, vol. 113, no. 8, pp. 1845–1855, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. O. Jung, S. Choi, S. B. Jang et al., “Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells,” Journal of Cell Science, vol. 125, no. Part 24, pp. 5960–5973, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. O. Jung, Y. J. Choi, T. K. Kwak et al., “The COOH-terminus of TM4SF5 in hepatoma cell lines regulates c-Src to form invasive protrusions via EGFR Tyr845 phosphorylation,” Biochimica et Biophysica Acta, vol. 1833, no. 3, pp. 629–642, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Ryu, M. Kang, M.-S. Lee et al., “Cross talk between the TM4SF5/focal adhesion kinase and the interleukin-6/STAT3 pathways promotes immune escape of human liver cancer cells,” Molecular and Cellular Biology, vol. 34, no. 16, pp. 2946–2960, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Turkson, T. Bowman, R. Garcia, E. Caldenhoven, R. P. De Groot, and R. Jove, “Stat3 activation by Src induces specific gene regulation and is required for cell transformation,” Molecular and Cellular Biology, vol. 18, no. 5, pp. 2545–2552, 1998. View at Publisher · View at Google Scholar
  16. E. Bournazou and J. Bromberg, “Targeting the tumor microenvironment: JAK-STAT3 signaling,” JAKSTAT, vol. 2, no. 2, p. e23828, 2013. View at Publisher · View at Google Scholar
  17. J. G. Cheong, D. G. Song, H. E. Song et al., “Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment,” Oncotarget, 2017. View at Publisher · View at Google Scholar
  18. S. Y. Lee, Y. T. Kim, M. S. Lee et al., “Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment,” Experimental Cell Research, vol. 312, no. 16, pp. 2983–2999, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. M. S. Lee, H. P. Kim, T. Y. Kim, and J. W. Lee, “Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition,” Biochimica et Biophysica Acta, vol. 1823, no. 2, pp. 514–523, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Kang, S. Choi, S. J. Jeong et al., “Cross-talk between TGFbeta1 and EGFR signalling pathways induces TM4SF5 expression and epithelial-mesenchymal transition,” The Biochemical Journal, vol. 443, no. 3, pp. 691–700, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. J. W. Lee, “Transmembrane 4 L six family member 5 (TM4SF5)-mediated epithelial-mesenchymal transition in liver diseases,” International Review of Cell and Molecular Biology, vol. 319, pp. 141–163, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Severi, H. van Malenstein, C. Verslype, and J. F. van Pelt, “Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification, and therapeutic targets,” Acta Pharmacologica Sinica, vol. 31, no. 11, pp. 1409–1420, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. S. A. Lee, S. Y. Lee, I. H. Cho et al., “Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma,” The Journal of Clinical Investigation, vol. 118, no. 4, pp. 1354–1366, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. M. Kang, S. J. Jeong, S. Y. Park et al., “Antagonistic regulation of transmembrane 4 L6 family member 5 attenuates fibrotic phenotypes in CCl(4)-treated mice,” The FEBS Journal, vol. 279, no. 4, pp. 625–635, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Reichl, C. Haider, M. Grubinger, and W. Mikulits, “TGF-beta in epithelial to mesenchymal transition and metastasis of liver carcinoma,” Current Pharmaceutical Design, vol. 18, no. 27, pp. 4135–4147, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. W. Zhong, W. F. Shen, B. F. Ning et al., “Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats,” Hepatology, vol. 50, no. 5, pp. 1524–1536, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. A. M. Gressner and R. Weiskirchen, “Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets,” Journal of Cellular and Molecular Medicine, vol. 10, no. 1, pp. 76–99, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. N. M. Meindl-Beinker and S. Dooley, “Transforming growth factor-beta and hepatocyte transdifferentiation in liver fibrogenesis,” Journal of Gastroenterology and Hepatology, vol. 23, Supplement 1, pp. S122–S127, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. F. Muller-Pillasch, C. Wallrapp, U. Lacher et al., “Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer,” Gene, vol. 208, no. 1, pp. 25–30, 1998. View at Publisher · View at Google Scholar · View at Scopus