Review Article

The Role of Defensins in HIV Pathogenesis

Table 1

Cellular sources and tissue localization of α-defensins.

HNP1–3HNP4aHD5HD6aReferences

Cellular (primary)NeutrophilsNeutrophilsPaneth cellsPaneth cells[23, 24, 42, 47, 124128]
Cellular (also reported)Monocytes, NK cells, B cells, γδ T cells, intestinal epithelial cellsFemale reproductive tract epithelial cells, urinary tract epithelial cells
TissuebCervical mucus plug, spleen, thymus

aLimited data available due to lack of availability of antibodies. bmRNA expression was identified in tissue but cellular source was not determined.