Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2017, Article ID 5217967, 14 pages
https://doi.org/10.1155/2017/5217967
Review Article

Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration

1Cardiovascular Stem Cell Research Laboratory, Wexner Medical Center, The Ohio State University, Columbus, OH, USA
2Vascular Biology and Stem Cell Research Laboratory, Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA

Correspondence should be addressed to Hiranmoy Das; ude.cshutt@sad.yomnarih

Received 13 May 2017; Revised 14 August 2017; Accepted 13 September 2017; Published 29 October 2017

Academic Editor: Juarez A. S. Quaresma

Copyright © 2017 Suman Kanji and Hiranmoy Das. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cutaneous wound healing is a complex multiple phase process, which overlaps each other, where several growth factors, cytokines, chemokines, and various cells interact in a well-orchestrated manner. However, an imbalance in any of these phases and factors may lead to disruption in harmony of normal wound healing process, resulting in transformation towards chronic nonhealing wounds and abnormal scar formation. Although various therapeutic interventions are available to treat chronic wounds, current wound-care has met with limited success. Progenitor stem cells possess potential therapeutic ability to overcome limitations of the present treatments as it offers accelerated wound repair with tissue regeneration. A substantial number of stem cell therapies for cutaneous wounds are currently under development as a result of encouraging preliminary findings in both preclinical and clinical studies. However, the mechanisms by which these stem cells contribute to the healing process have yet to be elucidated. In this review, we emphasize on the major treatment modalities currently available for the treatment of the wound, role of various interstitial stem cells and exogenous adult stem cells in cutaneous wound healing, and possible mechanisms involved in the healing process.