Advances of Stem Cell Therapeutics in Cutaneous Wound Healing and Regeneration

Table 1

Overview of stem cell-based therapies for cutaneous wound management in vivo and their mechanism of action.

Wound model	Type of cell therapy	Regenerative mechanisms	Reference
Excisional wound splinting model/Balb/C mice	BM-MSC	Recruitment of macrophages and endothelial lineages by paracrine factors	[124]
Excisional wound splinting model/diabetic mice	BM-MSC	Differentiation and angiogenesis	[129]
Excisional wound splinting model/C57BL/6 J mice	GMSC	Immunomodulation, M2 macrophage polarization	[118]
Full-thickness excisional wound/STZ-induced diabetic rat	ASC	Differentiation and vasculogenesis	[130]
Full-thickness excisional wound/STZ-induced diabetic mice	Human blood-derived CD34+ cells	Vasculogenesis	[103]
Limb ischemia and wounding/STZ-induced diabetic mice	Human fetal aorta-derived CD133+ cells	Paracrine stimulation of angiogenesis and activation of Wnt signaling	[105]
Full-thickness excisional wound in NOD/SCID mice	Nanofiber-expanded cord blood-derived CD34+ cells	Fibroblast proliferation and enhancement of collagen deposition and decreased MMP expression	[101]
Full-thickness excisional wound in NOD/SCID mice	Nanofiber-expanded cord blood-derived CD34+ cells	Immunomodulation, angiogenesis	[102]

BM-MSC: bone marrow-derived mesenchymal stem cells; GMSC: human gingiva-derived MSC; STZ: streptozotocin; ASC: adipose-derived stem cells.