Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma

<div>Tomatidine suppressed cytokine and chemokine levels in BEAS-2B cells. BEAS-2B cells treated with the indicated concentrations of tomatidine (Tom) for 1 h were cultured with 20 ng/ml TNF-<i>α</i> and 5 ng/ml IL-4 for 24 h. The supernatant was collected and the levels of IL-6, IL-8, ICAM-1, and CCL11 were measured by ELISA. 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Mediators of Inflammation

fig7

Figure 7

Figure 7: Tomatidine Attenuates Airway Hyperresponsiveness and Inflammation by Suppressing Th2 Cytokines in a Mouse Model of Asthma 