Adipokine Contribution to the Pathogenesis of Osteoarthritis

Figure 7

Chemerin signaling. Chemerin binds to three different G protein-coupled receptors: CMKLR1 (chemokine-like receptor 1), GPR1 (G protein-coupled receptor 1), and CCRL2 (chemokine (CC motif) receptor-like 2). The latter does not transduce any signal; once activated, CMKLR1 and GPR1 stimulate or inhibit different signaling pathways including MAPK ERK1/2, Akt, and AMPK to regulate different biological processes such as angiogenesis, inflammation, and steroidogenesis.