Curcumin Attenuation of Wear Particle-Induced Osteolysis via RANKL Signaling Pathway Suppression in Mouse Calvarial Model

Figure 6

Schematic representation of the molecular mechanisms of curcumin action in particle-induced osteolysis. CUR markedly reduced the secretion of inflammatory cytokines. Furthermore, CUR downregulated the osteoclast-specific gene expression and reversed the receptor activator of nuclear factor kappa-B ligand (RANKL)/osteoprotegerin ratio in PMMA particle-stimulated mice.