5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice

Figure 6

Lack of 5-HT alleviates histopathology damage and organ dysfunction in the kidney in CLP-induced sepsis in mice. The animal blood samples and the kidney tissues were harvested at 6 h or 24 h after the CLP administration. H&E staining was conducted as described above. In the kidney, the mice in the KO-CLP sepsis group had less inflammatory cell infiltration, necrosis, and degeneration. The BUN was calculated as an assessment of renal dysfunction (, BUN: mean ± SD, versus the WT-CLP group at 6 h after the CLP administration; versus the WT-CLP group at 24 h after the CLP administration).