5-HT Drives Mortality in Sepsis Induced by Cecal Ligation and Puncture in Mice

Figure 7

Lack of 5-HT alleviates the histopathology damage and organ dysfunction in the intestine in CLP-induced sepsis in mice. The intestine tissues were harvested at 6 h or 24 h after CLP administration. H&E staining was conducted as described above. In the intestine sections, the KO-CLP mice showed a reduced infiltration of inflammatory cells, edema in the space bounded by the villus, and separation of the epithelium from the basement membrane. The villus height was measured as an assessment of intestine dysfunction (, villus height: mean ± SD, versus the WT-CLP group at 6 h after the CLP administration; versus the WT-CLP group at 24 h after the CLP administration).