Research Article

Intranasal Delivery of miR-146a Mimics Delayed Seizure Onset in the Lithium-Pilocarpine Mouse Model

Figure 2

Behavioral observations within 2 h of pilocarpine administration. (a) Compared to the APE group, the percent of no induced seizures in the APT group increased by 6.7%; (b) the percentages of generalized convulsions were analyzed at different times after pilocarpine administration (0–10, 10–20, and ≥20 min) and revealed that the latency to generalized convulsions in the APT group was extended compared to the APE group; (c) the percentages of Racine levels (0–2 and ≥3) were analyzed based on the Racine scale and revealed that seizure severity in the APT group was reduced compared to the APE group.
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