Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM<sub>2.5</sub>, Budesonide, and Cotreated Exposures

<div>Cell viability assays for GSH, PM<sub>2.5</sub> extracts, budesonide (BUD), and the Co-T. BEAS-2B were treated for 24 hr with each treatment. (a) The 25 <i>μ</i>g/ml dose of GSH was selected as the highest nontoxic concentration and used as the positive control for ABCC1–4 gene expression experiments. (b) The highest nontoxic concentration of PM<sub>2.5</sub> extracts selected for further experiments was 25 <i>μ</i>g/ml. (c) The highest nontoxic concentration for the BUD exposure was 0.05 <i>μ</i>g/ml. (d) Using the nontoxic concentrations of PM<sub>2.5</sub> and BUD, a Co-T was established. 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Triton-X (25 <i>μ</i>g/ml) was used as positive control (+CNT). 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Mediators of Inflammation

fig1

Figure 1

Figure 1: Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM<sub>2.5</sub>, Budesonide, and Cotreated Exposures 

Figure 1 | Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM2.5, Budesonide, and Cotreated Exposures 