Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM<sub>2.5</sub>, Budesonide, and Cotreated Exposures

<div>BEAS-2B respond to PM<sub>2.5</sub> organic extracts. Local particle pollution has the capacity to generate ROS triggering the activation of Nrf2 and inducing the synthesis of antioxidant mRNAs: HMOX1 (heme oxygenase 1) and GSTP1 (glutathione-S-transferase). The antioxidant capacity is reduced provoking oxidative stress and the synthesis of ABCC1 and 4 and IL-6 and IL-8 mRNAs and their respective proteins.</div>

Mediators of Inflammation

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Figure 4

Figure 4: Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM<sub>2.5</sub>, Budesonide, and Cotreated Exposures 

Figure 4 | Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM2.5, Budesonide, and Cotreated Exposures 