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Mediators of Inflammation
Volume 2017, Article ID 6848430, 13 pages
https://doi.org/10.1155/2017/6848430
Research Article

Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor

1Emergency Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China
2Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, China
3Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China

Correspondence should be addressed to Yong-Ming Yao; moc.anis@ff_c and Zhong-qiu Lu; moc.361@518046_qzl

Received 8 September 2016; Revised 7 November 2016; Accepted 5 December 2016; Published 8 February 2017

Academic Editor: Eugenio A. C. Silva

Copyright © 2017 Guang-ju Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1: Protein levels of Axl and Mer in CD4+CD25− T cells.

Figure S2: Detection of TAM receptors on CD4+CD25+Tregs surface using a fluorescence microscopy.

Figure S3: Effects of Gas6 on TGF-β1 production in CD4+CD25+Tregs in vitro.

Figure S4: The transfection efficiency of lentiviral vectors for CD4+CD25+Tregs.

Figure S5: Effects of knockdown of Axl on TGF-β1 production by Tregs and IL-2 levels in co-culture supernatants.

  1. Supplementary Material