Associations of Functional MicroRNA Binding Site Polymorphisms in IL23/Th17 Inflammatory Pathway Genes with Gastric Cancer Risk

Table 1

SNPs of IL17A, IL23R, and IL17RA 3-UTRs within miRNA binding sites.

Gene	SNP	MAF	Predicted miRNA binding	ΔΔG (kJ/mol)
IL17A	rs3748067	0.13	hsa-miR-10a-3p	−9.59
IL23R	rs10889677	0.29	hsa-miR-1827	−19.12
			hsa-miR-5680	−10.37
IL17RA	rs1468488	0.08	hsa-miR-320a	−25.44
			hsa-miR-320b	−21.68
			hsa-miR-320c	−19.96
			hsa-miR-320d	−17.64
			hsa-miR-320e	−16.75
			hsa-miR-513c-5p	−19.47
			hsa-miR-514b-5p	−19.52
	rs887796	0.18	hsa-miR-4761-3p	−16.16

SNP: single-nucleotide polymorphism; MAF: minor allele frequency.