Associations of Functional MicroRNA Binding Site Polymorphisms in IL23/Th17 Inflammatory Pathway Genes with Gastric Cancer Risk
Table 4
Logistic regression analysis of associations between four miRNA binding site SNPs and GC risk.
Cases (%)
Controls (%)
a
OR (95% CI)b
b
OR (95% CI)c
c
()
()
rs3748067
CC
393 (78.60)
339 (67.80)
1.00
1.00
CT
104 (20.80)
154 (30.80)
0.58 (0.44, 0.78)
<0.01
0.59 (0.44, 0.79)
<0.01
TT
3 (0.60)
7 (1.40)
0.07
0.37 (0.10. 1.44)
0.76
0.39 (0.10, 1.54)
0.18
TT + CT
107 (21.40)
161 (32.20)
0.57 (0.43, 0.76)
0.01
0.58 (0.43, 0.77)
<0.01
C
890 (89.00)
832 (83.20)
1.00
1.00
T
110 (11.00)
168 (16.8)
0.61 (0.47, 0.79)
0.01
0.77 (0.47, 0.80)
<0.01
rs10889677
AA
252 (50.40)
274 (54.80)
1.00
1.00
AC
204 (40.80)
205 (41.00)
1.08 (0.84, 1.40)
0.55
1.07 (0.82, 1.39)
0.61
CC
44 (8.80)
21 (4.20)
0.10
2.28 (1.32, 3.94)
<0.01
2.22 (1.27, 3.87)
<0.01
CC + AC
248 (49.60)
226 (45.20)
1.19 (0.93, 1.53)
0.16
1.18 (0.92, 1.52)
0.20
A
708 (70.80)
753 (75.30)
1.00
1.00
C
292 (29.20)
247 (24.70)
1.26 (1.03, 1.53)
0.02
1.24 (1.02, 1.52)
0.03
rs1468488
TT
431 (86.20)
424 (84.80)
1.00
1.00
CT
67 (13.40)
75 (15.00)
0.88 (0.62, 1.25)
0.48
0.82 (0.57, 1.18)
0.28
CC
2 (0.40)
1 (0.20)
0.47
1.97 (0.18, 21.78)
0.58
1.84 (0.17, 20.49)
0.62
CC + CT
69 (13.80)
76 (15.20)
0.91 (0.64, 1.29)
0.58
0.83 (0.58, 1.13)
0.32
T
929 (92.90)
923 (92.30)
1.00
C
71 (7.10)
77 (7.70)
0.92 (0.66, 1.28)
0.61
0.86 (0.61, 1.21)
0.38
rs887796
AA
385 (77.00)
387 (77.40)
1.00
1.00
AG
104 (20.80)
101 (20.20)
1.04 (0.76, 1.41)
0.83
1.09 (0.80, 1.49)
0.59
GG
11 (2.20)
12 (2.40)
0.23
0.92 (0.40, 2.11)
0.85
0.94 (0.41, 2.18)
0.89
GG + AG
115 (23.00)
113 (22.60)
1.02 (0.76, 1.38)
0.88
1.08 (0.80, 1.45)
0.64
A
874 (87.40)
875 (87.50)
1.00
1.00
G
126 (12.60)
125 (12.50)
1.01 (0.78, 1.32)
0.95
1.05 (0.80, 1.37)
0.72
GC: gastric cancer; SNP: single-nucleotide polymorphism; OR: odds ratio; CI: confidence interval. a value for Hardy-Weinberg equilibrium in controls. bOR with 95% CI and value for unadjusted logistic regression analysis. cOR with 95% CI and value for logistic regression analysis adjusted for smoking, drinking, and family history of GC.
