Associations of Functional MicroRNA Binding Site Polymorphisms in IL23/Th17 Inflammatory Pathway Genes with Gastric Cancer Risk

Table 7

Combined effect of the four miRNA binding site SNPs on GC risk.

Combined effect of risk alleles^a	Cases (%)	Controls (%)	χ^2	Ptrend	OR (95% CI)
0-1	328 (65.60)	320 (64.00)			1.00
2-3	161 (32.20)	170 (34.00)	0.34	0.56	0.92 (0.71, 1.20)
4-5	11 (2.20)	10 (2.00)	0.03	0.87	1.07 (0.45, 2.56)
			0.18	0.67
Total	500 (100)	500 (100)

GC: gastric cancer; SNP: single-nucleotide polymorphism; OR: odds ratio; CI: confidence interval. ^aThe risk alleles: rs3748067T, rs10889677C, rs1468488C, and rs887796G.