Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia

<div>OPN polarizes astrocytes towards the infarct. (a) Infarct margin stained for GFAP showing the majority of astrocytes with processes aligned towards the infarct core in OPN-treated animals, and increased process length in OPN-treated animals. Quantification of changes in polarisation (b) and process length (c). 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Mediators of Inflammation

fig5

Figure 5

Figure 5: Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia 