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Mediators of Inflammation
Volume 2017, Article ID 7215072, 13 pages
https://doi.org/10.1155/2017/7215072
Review Article

Contribution of In Vivo and Organotypic 3D Models to Understanding the Role of Macrophages and Neutrophils in the Pathogenesis of Psoriasis

1Centre LOEX de l’Université Laval, Génie Tissulaire et Régénération, Centre de Recherche FRQS du CHU de Québec, Axe Médecine Régénératrice, Québec, QC, Canada
2Faculté de Pharmacie, Université Laval, Québec, QC, Canada
3L’Oréal Research & Innovation, Aulnay-sous-Bois, France
4Episkin Academy, Lyon, France

Correspondence should be addressed to Roxane Pouliot; ac.lavalu.ahp@toiluop.enaxor

Received 19 May 2017; Revised 15 September 2017; Accepted 2 October 2017; Published 8 November 2017

Academic Editor: Anna Balato

Copyright © 2017 Isabelle Lorthois et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Psoriasis, a common chronic immune-mediated skin disease, is histologically characterized by a rapid keratinocyte turnover and differentiation defects. Key insights favor the idea that T cells are not the only key actors involved in the inflammatory process. Innate immune cells, more precisely neutrophils and macrophages, provide specific signals involved in the initiation and the maintenance of the pathogenesis. Current data from animal models and, to a lesser extent, three-dimensional in vitro models have confirmed the interest in leaning towards other immune cell types as a potential new cellular target for the treatment of the disease. Although these models do not mimic the complex phenotype nor all human features of psoriasis, their development is necessary and essential to better understand reciprocal interactions between skin cells and innate immune cells and to emphasize the crucial importance of the local lesional microenvironment. In this review, through the use of in vivo and 3D organotypic models, we aim to shed light on the crosstalk between epithelial and immune components and to discuss the role of secreted inflammatory molecules in the development of this chronic skin disease.