All-Trans Retinoic Acid Modulates TLR4/NF-κB Signaling Pathway Targeting TNF-α and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer

Table 2

Sera TNF-α and NO concentrations in patients with ulcerative colitis and colitis associated cancer.

	[TNF-α] (pg/ml)	NO (μM)
UC ()	291,48 ± 19,03 ( 0,001)	45,67 ± 6,14 ( 0,001)
CAC ()	374,7 ± 16,42 ( 0,001)	43,91 ± 7,28 ( 0,001)
HD ()	18,54 ± 5,31	21,32 ± 5,16

Values represent the mean ± standard deviation.
Significance compared with healthy donors: .
TNF-α: significant difference between the two groups of patients (active UC/CAC) is indicated ().
NO: no significant difference between the two groups of patients (UC/CAC) is indicated ().
HD, healthy donors; UC, ulcerative colitis; CAC, colitis associated cancer.