TSG-6 Downregulates IFN-Alpha and TNF-Alpha Expression by Suppressing IRF7 Phosphorylation in Human Plasmacytoid Dendritic Cells

Figure 1

TSG-6 decreased TLR7/9 mediated TNF-α and IFN-α production in GEN2.2 cells. ELISA analysis of TNF-α (a) and IFN-α (b) in GEN2.2 cells treated with TSG-6 (1000 ng/mL) overnight, with or without stimulation with CpG-A at 2 μM or R837 at 10 ng/mL for 6 hours. Graphs show data from three independent experiments performed in duplicate. Error bars indicate SEM. Paired Student’s -test, , , and .

(a)

(b)