Illicium verum Extract and Trans-Anethole Attenuate Ovalbumin-Induced Airway Inflammation via Enhancement of Foxp3⁺ Regulatory T Cells and Inhibition of Th2 Cytokines in Mice

Figure 1

Effect of Illicium verum extract (IVE) and trans-anethole (AET) on airway hyperresponsiveness and serum IgE levels. (a) Schematic diagram of methacholine-induced airway hyperresponsiveness in mice. (b) Airway responsiveness to aerosolized methacholine (Penh) in each treatment group. (c) OVA-specific IgE levels in serum of OVA-induced mice. Results are expressed as mean ± SEM ( per group). and indicate statistically significant differences between the asthma control group and drug-treated group. Normal group: untreated Balb/c mice; OVA-Control: untreated OVA-induced asthma mice; OVA-CsA: CsA- (10 mg/kg) treated OVA mice; OVA-IVE: IVE- (200 mg/kg) treated OVA mice; OVA-AET: AET- (20 mg/kg and 2 mg/kg) treated OVA mice.

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