Oral Administration of Resveratrol Alleviates Osteoarthritis Pathology in C57BL/6J Mice Model Induced by a High-Fat Diet

Figure 2

Oral resveratrol prevents articular cartilage damage in a HFD induced OA model. (a) Articular staining of mice fed with HFD at the end of 16 weeks (CON and HFD, ). (b) Articular staining of mice after resveratrol treatment at the end of 28 weeks ( per group); (A) H & E (original magnification, 200x); (B) Safranin O (original magnification, 40x); and (C) Safranin O/Fast Green (original magnification, 40x). (c) Modified Mankin scores. Scale bars = 100 μm. One-way ANOVA was used to test for statistical significance. Data were expressed as the mean ± SEM. , versus the CON group; versus the HFD-S group.

(a)

(b)

(c)