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Mediators of Inflammation
Volume 2017 (2017), Article ID 7682083, 9 pages
Research Article

Progranulin Inhibits Human T Lymphocyte Proliferation by Inducing the Formation of Regulatory T Lymphocytes

Institute of Oral Biology, School of Dentistry, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

Correspondence should be addressed to Hyeon-Woo Lee

Received 12 October 2016; Revised 5 December 2016; Accepted 27 December 2016; Published 17 January 2017

Academic Editor: Jagadeesh Bayry

Copyright © 2017 Kyu Hwan Kwack and Hyeon-Woo Lee. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We have examined the effect of progranulin (PGRN) on human T cell proliferation and its underlying mechanism. We show that PGRN inhibits the PHA-induced multiplication of T lymphocytes. It increases the number of iTregs when T lymphocytes are activated by PHA but does not do so in the absence of PHA. PGRN-mediated inhibition of T lymphocyte proliferation, as well as the induction of iTregs, was completely reversed by a TGF-β inhibitor or a Treg inhibitor. PGRN induced TGF-β secretion in the presence of PHA whereas it did not in the absence of PHA. Our findings indicate that PGRN suppresses T lymphocyte proliferation by enhancing the formation of iTregs from activated T lymphocytes in response to TGF-β.